SmartFlow Technologies, based in Apex, N.C., and G&G Technologies, located in North Kingstown, R.I., launched the WholeStream Bioprocessor Model 50-3000, the first system in the WholeStream family that incorporates a 50L G&G Omni Bioreactor system with a SmartFlow Technologies disposable OptiSep 3000 module and Pegasus system technology. The system's total operation is controlled with a single, integrated control and HMI screen, with any additional unit operations (ultrafiltration or chromatography) being integrated as needed in a "plug-and-play" fashion.

The use of an integrated, uniform HMI across all operations provides users the benefits of an easy-to-navigate and customizable system for training and operation. The WholeStream BioProcessor can function as a single-use disposable bioreactor/cell harvest system or provide multiple-usage capability with low volume 316L stainless-steel piping. For true modular operation, companies can integrate a SmartFlow Technologies ultrafiltration system with supporting OptiSep modules and/or a SmartFlow Technologies chromatography system with customer-defined column and media components. Each unit operation is fully automated and can be integrated into a facility’s existing system or function as a stand-alone feature.

The WholeStream redefines traditional upstream and downstream processing in a breakthrough product combining a bioreactor with membrane cell harvest, clarification and concentration into a fully integrated, automated, modular and single-use system.

The WholeStream approach brings together SmartFlow and G&G’s broad and deep knowledge to provide a bioreactor unit that works integrally with a cell harvest unit and optional ultrafiltration and/or chromatography unit operations.

For more information, please contact SmartFlow Technologies or G&G Technologies at or, respectively.