A new study published in the American Journal of Clinical Nutrition (June 23, 2010) demonstrates how DSM Nutritional Products’ weight management ingredient Fabuless exerts its appetite-reducing effects.

A new study published in the American Journal of Clinical Nutrition (June 23, 2010) demonstrates how DSM Nutritional Products’ weight management ingredient Fabuless exerts its appetite-reducing effects. Highlighting differences in digestion between Fabuless and a control fat by an established intestinal sampling technique, the results further substantiate the mechanism behind the reported weight maintenance benefits of Fabuless. 

The controlled, double-blind, cross-over-designed study investigated the mechanism behind the appetite-controlling effect of Fabuless on a group of 16 subjects with healthy weight. Compared to a control milk fat, the fat derived from Fabuless was found to resist absorption, leading to almost double the amount of lipids progressing from the upper gastrointestinal tract to the sampling site in the small intestine. Interestingly, fatty acid-containing crystals were observed in abundance in the Fabuless group. The higher amount of lipids in the middle section of the small intestine and the presence of fatty acid crystals offer coherent evidence for enhanced appetite control through the ileal brake mechanism. In contrast to previous studies in which lipids were infused into the intestine, this unique technique enables the examination of lipids through the natural digestive route.

“We are very pleased with these results as they provide an in-depth understanding of the mechanism behind the appetite-reducing effect of Fabuless,” says Philip Rijken, head of nutritional science-Europe and Asia Pacific at DSM Nutritional Products. “The new evidence further validates the enhanced appetite-control response to Fabuless by detailing its physiological basis. The data add to a previous mechanism-of-action study showing that Fabuless induces a significant delay in food transit time. We expect that these latest insights into the mechanism of action will be received with a lot of interest by the scientific community.”

DSM’s proprietary Fabuless combines oat and palm oils, both naturally occurring dietary lipids. Fabuless contributes to the body’s appetite regulation. In particular, it enhances the “appetite satisfied” message from the gut system to the brain as part of the body’s normal regulatory mechanism related to energy intake. Fabuless can be consumed on its own or as the key ingredient in a variety of applications including milk, yogurt, meal replacer drinks and supplement sachets and beverage sticks.

DSM Nutritional Products
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